Sperm DNA Fragmentation


In order for a spermatozoon to be fertile, the chromatin must decondense correctly after fertilization. Nuclear alterations, such as an abnormal chromatin structure, micro-deletions in the chromosome, or DNA fragmentation, will all reduce the sperm cell’s ability to produce a viable embryo. Sperm DNA Fragmentation (SDF) is inversely related to the sperm cell’s ability to fertilize. Thus, when the percentage of cells with SDF is high, the less likely it will be that a spermatozoon from that semen sample successfully fertilizes an egg. Numerous scientific publications have demonstrated that an SDF value that exceeds 30% suggests sub-par sperm quality. There exist numerous causes for Sperm DNA Fragmentation including: increased testicular temperature due to tight clothing, bouts of fever or varicocele; the presence of reactive oxygen species in the semen; the metabolic effects of overweight such as high insulin levels; smoking; certain drugs such as certain serotonin re-uptake inhibitors; and age. pproximately 25% of infertile males present elevated SDF values. Approximately 10% of infertile patients presenting spermiograms that are considered normal have an SDF value that is considered pathological. Thus, Sperm DNA Fragmentation is considered an independent and complementary parameter in the assessment of semen quality to concentration, morphology and motility. Measuring sperm DNA fragmentation confers clinicians and scientists the power to make more informed decisions in their daily practice and take action based on quantitative results:

- To distinguish which couples are suitable for treatment by intra-uterine insemination.
- To assess the quality of semen samples or donors for suitability.
- To assess the efficacy of medical interventions or treatments of infectious diseases.
- To provide answers to cases of unexplained infertility, ART failure or repeated abortions.
- To provide a quality control in improving semen handling or cryopreservation protocols.
Source: Gutenberg Reproduction Clinic

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Gutenberg Reproduction Clinic
Calle Gutenberg, 5


Obstetrics & Gynaecology,Assisted Reproduction
Obstetrics & Gynaecology,Assisted Reproduction
Obstetrics & Gynaecology,Assisted Reproduction
Obstetrics & Gynaecology,Assisted Reproduction
Obstetrics & Gynaecology,Assisted Reproduction